mammalian mRNA

Development of m1A-seq to map a newly identified constituent of mammalian mRNA

YTHDF2 selectively binds m6A-containing RNA

YTHDF2 selectively binds m6A-containing RNA

m6A switches

m6A switches

m6A alters RNA structure to enhance HNRNPC binding

m6A alters RNA structure to enhance HNRNPC binding

 mRNA processing promotes translation and decay

m6A-dependent mRNA processing promotes translation and decay, and affects splicing

Figure Abstract

ALKBH1-Mediated tRNA Demethylation Regulates Translation

University of Chicago Laboratory Center

News

10/19/2016 A new research center led by UChicago scientists will develop unprecedented technologies to decode RNA modifications, the next layer of gene expression control. The $10.6 million, five-year award from the National Human Genome Research Institute will establish Chicago’s first Center of Excellence in Genomic Science—one of only seven such centers in the United States.
Read More

2/8/17 Two Pilots Awards from CDRE have been granted to Professors Xiaoxi Zhuang and Jingyi Fei.

Events

Seminar

June 19-20, 2017
Professor Dr. Xin He and Drs. Qili Fei and Yuwen Liu
"Bioinformatics for Next Generation Sequencing Data Analysis"
http://www.cegs-cdre.org/outreach/

 

 

Talk

3/10/2017
Professor Dr. Mark Helm
Johannes Gutenberg-Universität Mainz
Institute of Pharmacy and Biochemistry
"Quantification of RNA and its modificacions"
https://www.ak-helm.pharmazie.uni-mainz.de

 

 

Talk

10/27/2016
Professor Dr. Christian Hackenberger
Leibniz-Institut für Molekulare Pharmakologie (FMP) 
"The power of chemoselectivity: Site-specific modification and cellular uptake of functional proteins"
http://www.leibniz-fmp.de/research/chemical-biology/res-groups-chembio/hackenbe/intro.html

 

 

 

Conference

10/19-20/2016
Centers of Excellence in Genomic Science CEGS
14th Annual Grantee Meeting
Standford University, Palo Alto, CA  

Conference

9/8-9/2016
Abcam RNA Modifications and Transcriptomics 

Talk

9/6/2016
Dr. Neal Devaraj
Associate Professor of Chemistry and Biochemistry at the University of California, San Diego (UCSD)
“In situ chemistry for detecting and manipulating RNA”
http://www.devarajgroup.com/