mammalian mRNA

Development of m1A-seq to map a newly identified constituent of mammalian mRNA

YTHDF2 selectively binds m6A-containing RNA

YTHDF2 selectively binds m6A-containing RNA

m6A switches

m6A switches

m6A alters RNA structure to enhance HNRNPC binding

m6A alters RNA structure to enhance HNRNPC binding

 mRNA processing promotes translation and decay

m6A-dependent mRNA processing promotes translation and decay, and affects splicing

Figure Abstract

ALKBH1-Mediated tRNA Demethylation Regulates Translation

University of Chicago Laboratory Center

News

Jan 22 2020, UChicago News:

He Lab breakthrough has major implications in basic biology

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Jan 16 2020, Science:

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.

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Dec 23 2019, Genome Biology:

RADAR, a comprehensive analytical tool for detecting differentially methylated loci in MeRIP-seq data

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Events

Conference

11/4-5/2019
Centers of Excellence in Genomic Science CEGS
17th Annual Grantee Meeting
Harvard Medical School, Boston, MA  

Conference

6/17-18/2019
Abcam: Functions of Epitranscriptomes

Conference

11/19-20/2018
Centers of Excellence in Genomic Science CEGS
16th Annual Grantee Meeting
The University of Chicago, Chicago, IL  

Seminar

June 25-26, 2018
Professor Dr. Xin He and Drs. Qili Fei and Yuwen Liu
"Bioinformatics for Next Generation Sequencing Data Analysis"
http://www.cegs-cdre.org/outreach/

 

 

Conference

10/2-3/2017
Centers of Excellence in Genomic Science CEGS
15th Annual Grantee Meeting
Bell Harbor International Conference Center, Seattle, WA  

Seminar

June 19-20, 2017
Professor Dr. Xin He and Drs. Qili Fei and Yuwen Liu
"Bioinformatics for Next Generation Sequencing Data Analysis"
http://www.cegs-cdre.org/outreach/

 

 

Talk

3/10/2017
Professor Dr. Mark Helm
Johannes Gutenberg-Universität Mainz
Institute of Pharmacy and Biochemistry
"Quantification of RNA and its modificacions"
https://www.ak-helm.pharmazie.uni-mainz.de

 

 

Talk

10/27/2016
Professor Dr. Christian Hackenberger
Leibniz-Institut für Molekulare Pharmakologie (FMP) 
"The power of chemoselectivity: Site-specific modification and cellular uptake of functional proteins"
http://www.leibniz-fmp.de/research/chemical-biology/res-groups-chembio/hackenbe/intro.html

 

 

 

Conference

10/19-20/2016
Centers of Excellence in Genomic Science CEGS
14th Annual Grantee Meeting
Standford University, Palo Alto, CA  

Conference

9/8-9/2016
Abcam RNA Modifications and Transcriptomics 

Talk

9/6/2016
Dr. Neal Devaraj
Associate Professor of Chemistry and Biochemistry at the University of California, San Diego (UCSD)
“In situ chemistry for detecting and manipulating RNA”
http://www.devarajgroup.com/